4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Base Information

Chemical Name:4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane
CAS No.:142545-23-1
Molecular Formula:C₂₅H₃₃NO₅
Molecular Weight:427.541
Hs Code.:

Synonyms:4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Suppliers and Price of 4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

There total 10 articles about 4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 142545-24-2
4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-3(R)-hydroxyhexene-1

: 142545-23-1
4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 5 ℃; for 96h;
DOI:10.1016/S0040-4020(01)92199-4

Reference yield:

: 87219-29-2
benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate

: 142545-23-1
4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Guidance literature:: Multi-step reaction with 9 steps

1: 83 percent / dicyclohexylcarbodiimide / 72 h / Ambient temperature

2: 94 percent / imidazole / dimethylformamide / 2 h / 40 °C

3: 98 percent / H₂ / 5percent Pd/C / methanol / 8 h / Ambient temperature

4: 82 percent / LiAlH₄ / diethyl ether / 1) -25 deg C, 2) 0 deg C, 2 h

5: 74 percent / NaH / dimethylformamide / 2 h / Ambient temperature

6: 97 percent / Bu₄NF / tetrahydrofuran / 1 h / Ambient temperature

7: 95 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 0.25 h / Ambient temperature

8: 81 percent / diethyl ether / 1 h / -78 °C

9: 70 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 96 h / 5 °C

With 1H-imidazole; lithium aluminium tetrahydride; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)92199-4

Reference yield:

: 192517-47-8
methyl (3S)-3-[[(benzyloxy)carbonyl]amino]-4-hydroxybutanoate

: 142545-23-1
4(S)-(N-Benzyl-N-tert-butoxycarbonyl)amino-6-benzyloxy-1,2-2(S)-epoxy-3(S)-hydroxyhexane

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / imidazole / dimethylformamide / 2 h / 40 °C

2: 98 percent / H₂ / 5percent Pd/C / methanol / 8 h / Ambient temperature

3: 82 percent / LiAlH₄ / diethyl ether / 1) -25 deg C, 2) 0 deg C, 2 h

4: 74 percent / NaH / dimethylformamide / 2 h / Ambient temperature

5: 97 percent / Bu₄NF / tetrahydrofuran / 1 h / Ambient temperature

6: 95 percent / SO₃-pyridine, Et₃N / dimethylsulfoxide / 0.25 h / Ambient temperature

7: 81 percent / diethyl ether / 1 h / -78 °C

8: 70 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / 96 h / 5 °C

With 1H-imidazole; lithium aluminium tetrahydride; pyridine-SO₃ complex; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)92199-4