N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE

Base Information

• Chemical Name: N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE
• CAS No.: 16018-82-9
• Molecular Formula: C8H10 F N5
• Molecular Weight: 195.199
• Mol file: 16018-82-9.mol

Synonyms:Biguanide,1-(p-fluorophenyl)- (8CI)

Chemical Property of N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 1.72E-06mmHg at 25°C
• Refractive Index: 1.635
• Boiling Point: 396.3°Cat760mmHg
• Flash Point: 193.5°C
• PSA: 97.78000
• Density: 1.44g/cm³
• LogP: 2.01910

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE

There total 3 articles about N-(4-FLUOROPHENYL)IMIDODICARBONIMIDIC DIAMIDE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-Cyanoguanidine (127099-85-8,780722-26-1,461-58-5) + 4-fluoroaniline (371-40-4) → 1-carbamimidamido-N-(4-fluorophenyl)methanimidamide (16018-82-9)

Guidance literature:

N-Cyanoguanidine; 4-fluoroaniline; In toluene; at 20 ℃; for 0.25h;

With hydrogenchloride; In water; toluene; for 4h;

DOI:10.1155/2017/1212609

Reference yield:

1-carbamimidamido-N-(4-fluorophenyl)methanimidamide hydrochloride (16018-83-0,1258254-49-7) → 1-carbamimidamido-N-(4-fluorophenyl)methanimidamide (16018-82-9)

Guidance literature:

With sodium ethanolate; In ethanol; at 20 ℃; for 3h; Reagent/catalyst;

Reference yield:

→ 1-carbamimidamido-N-(4-fluorophenyl)methanimidamide (16018-82-9)

Guidance literature:

With hydrogenchloride; In acetonitrile; at 100 ℃;

upstream raw materials:

N-Cyanoguanidine

4-fluoroaniline

1-carbamimidamido-N-(4-fluorophenyl)methanimidamide hydrochloride

Refernces

• 1、 -. "PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING IMMUNE DISEASES OR INFLAMMATORY DISEASES, CONTAINING BIGUANIDE DERIVATIVE COMPOUND AS ACTIVE INGREDIENT". Paragraph 0085. . Retrieved 2017/12/27.
• 2、 Magri, Andrea,Reilly, Roisin,Scalacci, Nicolò,Radi, Marco,Hunter, Michael,Ripoll, Manon,Patel, Arvind H.,Castagnolo, Daniele. "Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents". supporting information. p. 5372 - 5376. Retrieved 2015/11/09.