(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Chemical Name:(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one
CAS No.:1579514-80-9
Molecular Formula:C₂₂H₂₇BrN₄O₂
Molecular Weight:459.386
Hs Code.:

Synonyms:(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Chemical Property of (R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Technology Process of (R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

There total 10 articles about (R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1579514-72-9
(R)-8-benzyl-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

: 1579514-80-9
(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: With carbonochloridic acid 1-chloro-ethyl ester; potassium hydrogencarbonate; In dichloromethane; for 1.5h; Reflux;

Reference yield: 99.0%

: 50893-53-3
carbonochloridic acid 1-chloro-ethyl ester

: 1579514-72-9
(R)-8-benzyl-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

: 1579514-80-9
(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: With potassium hydrogencarbonate; In methanol; dichloromethane; for 2.5h; Reflux;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1579514-80-9
(R)-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride; ammonia / water / 0.33 h / 20 °C

1.2: 24 h

2.1: sulfuric acid / dichloromethane / 0 - 5 °C

2.2: 10 °C / pH 9

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: sodium hydroxide / water; methanol / 24 h / 65 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 65 °C

6.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8.1: potassium hydrogencarbonate; carbonochloridic acid 1-chloro-ethyl ester / dichloromethane / 1.5 h / Reflux

With hydrogenchloride; carbonochloridic acid 1-chloro-ethyl ester; sulfuric acid; ammonia; potassium carbonate; ammonium chloride; benzotriazol-1-ol; potassium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;