(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

Base Information

Chemical Name:(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide
CAS No.:1384982-18-6
Molecular Formula:C₃₄H₃₇O₆PS
Molecular Weight:604.704
Hs Code.:

Synonyms:(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

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Chemical Property of (2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

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Technology Process of (2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

There total 3 articles about (2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1384981-99-0
(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane-2-oxide

: 1384982-18-6
(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

Guidance literature:: With Lawessons reagent; In toluene; at 85 ℃; for 24h; Inert atmosphere;
DOI:10.1021/ja305104b

Reference yield:

: 100-39-0
benzyl bromide

: 1384982-18-6
(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; tetra-n-butylammonium iodid / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2: Lawessons reagent / toluene / 24 h / 85 °C / Inert atmosphere

With Lawessons reagent; sodium hydride; tetra-n-butylammonium iodid; In tetrahydrofuran; toluene;
DOI:10.1021/ja305104b

Reference yield:

: (3S,4S,5S,6R)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)-3-hydroxy-2-methoxy-1,2-oxaphosphinane-2-oxide

: 1384982-18-6
(2R,3S,4S,5S,6R)-3,4,5-tris(benzyloxy)-6((benzyloxy)methyl)-2-methoxy-1,2-oxaphosphinane 2-sulfide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride; tetra-n-butylammonium iodid / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2: Lawessons reagent / toluene / 24 h / 85 °C / Inert atmosphere

With Lawessons reagent; sodium hydride; tetra-n-butylammonium iodid; In tetrahydrofuran; toluene;
DOI:10.1021/ja305104b