{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

Base Information

Chemical Name:{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester
CAS No.:1357588-10-3
Molecular Formula:C₁₉H₂₄FN₃O₃
Molecular Weight:361.416
Hs Code.:

Synonyms:{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

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Chemical Property of {2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

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Technology Process of {2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

There total 1 articles about {2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 903550-26-5
1-tetrahydropyran-1H-pyrazolylboronic ester

: 848440-23-3
(3-bromo-2-fluorophenyl)carbamic acid tert-butyl ester

: 1357588-10-3
{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

: 449758-17-2
1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 1357588-10-3
{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

: 1357588-11-4
[2-fluoro-3-(2H-pyrazol-3-yl)phenyl]carbamic acid tert-butyl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1357588-10-3
{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}carbamic acid tert-butyl ester

: 1357587-26-8
N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

2: N-Bromosuccinimide / dichloromethane / 17 h / 20 °C

3: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 4 h / 20 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

5: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6: pyridine / 1 h / 0 °C

With pyridine; N-Bromosuccinimide; tetrabutylammomium bromide; caesium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; dichloromethane; water;