N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

Base Information

Chemical Name:N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide
CAS No.:1357587-26-8
Molecular Formula:C₂₂H₁₈F₂N₄O₂S
Molecular Weight:440.473
Hs Code.:

Synonyms:N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

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Chemical Property of N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

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Technology Process of N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

There total 7 articles about N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 701-27-9
3-fluorobenzene-1-sulfonyl chloride

: 1357588-15-8
3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenylamine

: 1357587-26-8
N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

Guidance literature:: With pyridine; at 0 ℃; for 1h;

Reference yield:

: 848440-23-3
(3-bromo-2-fluorophenyl)carbamic acid tert-butyl ester

: 1357587-26-8
N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Microwave irradiation; Inert atmosphere

2: toluene-4-sulfonic acid / methanol / 2 h / 20 °C

3: N-Bromosuccinimide / dichloromethane / 17 h / 20 °C

4: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 4 h / 20 °C

5: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

6: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7: pyridine / 1 h / 0 °C

With pyridine; N-Bromosuccinimide; tetrabutylammomium bromide; caesium carbonate; toluene-4-sulfonic acid; trifluoroacetic acid; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; dichloromethane; water;

Reference yield:

: 1357588-11-4
[2-fluoro-3-(2H-pyrazol-3-yl)phenyl]carbamic acid tert-butyl ester

: 1357587-26-8
N-[3-(1-ethyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-2-fluorophenyl]-3-fluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / dichloromethane / 17 h / 20 °C

2: sodium hydroxide; tetrabutylammomium bromide / dichloromethane; water / 4 h / 20 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.5 h / 100 °C / Inert atmosphere; Microwave irradiation

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: pyridine / 1 h / 0 °C

With pyridine; N-Bromosuccinimide; tetrabutylammomium bromide; caesium carbonate; trifluoroacetic acid; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; dichloromethane; water;