(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

Base Information

Chemical Name:(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one
CAS No.:1621084-00-1
Molecular Formula:C₁₅H₁₇F₂NO₄
Molecular Weight:313.301
Hs Code.:

Synonyms:(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

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Chemical Property of (1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

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Technology Process of (1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

There total 12 articles about (1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1621083-99-5
(1S,8aR)-1-(benzyloxy)-8,8-difluoro-2,3,8,8a-tetrahydroindolizin-5(1H)-one

: 1621084-00-1
(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

Guidance literature:: With osmium(VIII) oxide; In water; acetone; at 20 ℃; for 48h;
DOI:10.1016/j.cclet.2014.04.018

Reference yield:

: 1621083-94-0
(3S,4R)-4-azido-3-(benzyloxy)-5,5-difluorohept-6-enyl acetate

: 1621084-00-1
(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium penicillin V / methanol / 1 h

2.1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C

3.1: triphenylphosphine / tetrahydrofuran; water / 4 h / 80 °C

4.1: potassium carbonate / dichloromethane / 12 h / 20 °C

5.1: titanium(IV) isopropylate / toluene / 3 h / Reflux; Irradiation

5.2: 10 h / Reflux

6.1: osmium(VIII) oxide / water; acetone / 48 h / 20 °C

With titanium(IV) isopropylate; dmap; osmium(VIII) oxide; potassium carbonate; potassium penicillin V; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; acetone; toluene;
DOI:10.1016/j.cclet.2014.04.018

Reference yield:

: 1621083-98-4
1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

: 1621084-00-1
(1S,6R,7S,8aR)-1-(benzyloxy)-8,8-difluoro-6,7-dihydroxyhexahydroindolizin-5(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) isopropylate / toluene / 3 h / Reflux; Irradiation

1.2: 10 h / Reflux

2.1: osmium(VIII) oxide / water; acetone / 48 h / 20 °C

With titanium(IV) isopropylate; osmium(VIII) oxide; In water; acetone; toluene;
DOI:10.1016/j.cclet.2014.04.018