1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Base Information

Chemical Name:1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one
CAS No.:1621083-98-4
Molecular Formula:C₁₇H₁₉F₂NO₂
Molecular Weight:307.34
Hs Code.:

Synonyms:1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Suppliers and Price of 1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

There total 10 articles about 1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1621083-97-3
1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

: 814-68-6,25189-84-8
acryloyl chloride

: 1621083-98-4
1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1016/j.cclet.2014.04.018

Reference yield:

: 1621083-94-0
(3S,4R)-4-azido-3-(benzyloxy)-5,5-difluorohept-6-enyl acetate

: 1621083-98-4
1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium penicillin V / methanol / 1 h

2: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C

3: triphenylphosphine / tetrahydrofuran; water / 4 h / 80 °C

4: potassium carbonate / dichloromethane / 12 h / 20 °C

With dmap; potassium carbonate; potassium penicillin V; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/j.cclet.2014.04.018

Reference yield:

: 82130-73-2
dimethyl (S)-(-)-2-benzyloxybutanedioate

: 1621083-98-4
1-((2R,3S)-3-(benzyloxy)-2-(1,1-difluoroallyl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 10 steps

1.1: magnesium bromide diethyl etherate / dichloromethane / 1 h / 0 °C

1.2: 2 h / -90 °C

1.3: -90 - 20 °C

2.1: indium / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C

4.1: lipase AK / 24 h / 20 °C / Enzymatic reaction

5.1: dmap / dichloromethane / -35 - 0 °C

6.1: sodium azide / N,N-dimethyl-formamide / 0 - 20 °C

7.1: potassium penicillin V / methanol / 1 h

8.1: triethylamine; dmap / dichloromethane / 12 h / 0 - 20 °C

9.1: triphenylphosphine / tetrahydrofuran; water / 4 h / 80 °C

10.1: potassium carbonate / dichloromethane / 12 h / 20 °C

With dmap; indium; lithium aluminium tetrahydride; sodium azide; magnesium bromide diethyl etherate; lipase AK; potassium carbonate; potassium penicillin V; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.cclet.2014.04.018