Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide

Base Information

Chemical Name:Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide
CAS No.:15979-14-3
Molecular Formula:C16H7 F12 O P
Molecular Weight:474.186
Hs Code.:
DSSTox Substance ID:DTXSID80475954
Wikidata:Q82306792
Mol file:15979-14-3.mol

Synonyms:15979-14-3;Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide;bis[3,5-bis(trifluoromethyl)phenyl]-oxophosphanium;Phosphine oxide, bis[3,5-bis(trifluoromethyl)phenyl]-;SCHEMBL7798380;DTXSID80475954;KQBXBLCCVYVZAV-UHFFFAOYSA-N;KQXSBRPPJOOITN-UHFFFAOYSA-N;CID 101769768;FT-0710967;Bis[3,5-bis(trifluoromethyl)phenyl](oxo)phosphanium

Suppliers and Price of Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
BIS(3,5-BIS(TRIFLUOROMETHYL)PHENYL)PHOSPHINE OXIDE 95.00%
5MG
$ 498.39

Total 7 raw suppliers

Chemical Property of Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide

Chemical Property:

Boiling Point:336.2±52.0 °C(Predicted)
PSA：40.54000
LogP:6.27230
XLogP3:6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:2
Exact Mass:472.9964648
Heavy Atom Count:30
Complexity:524

Purity/Quality:

98%min ^*data from raw suppliers

BIS(3,5-BIS(TRIFLUOROMETHYL)PHENYL)PHOSPHINE OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C=C1C(F)(F)F)[P+](=O)C2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)C(F)(F)F

Technology Process of Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide

There total 5 articles about Bis(3,5-bis(trifluoromethyl)phenyl)phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 15979-14-3
bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide

Guidance literature:: 3,6-bis(trifluoromethyl)bromobenzene; With magnesium; In tetrahydrofuran; at 0 - 20 ℃; for 20.25h; Inert atmosphere;

With phosphonic acid diethyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 20.25h; Inert atmosphere;
DOI:10.1002/adsc.201800723

Reference yield: 86.0%

: 328-70-1
3,6-bis(trifluoromethyl)bromobenzene

: 762-04-9
phosphonic acid diethyl ester

: 15979-14-3
bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide

Guidance literature:: 3,6-bis(trifluoromethyl)bromobenzene; With iodine; magnesium; In tetrahydrofuran; for 1h; Schlenk technique; Reflux; Inert atmosphere;

phosphonic acid diethyl ester; In tetrahydrofuran; at 0 - 20 ℃; Schlenk technique; Inert atmosphere;
DOI:10.1021/jacs.0c06581

Reference yield: 85.0%

: 328-72-3
3,5-(bistrifluoromethyl)chlorobenzene

: 15979-14-3
bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide

Guidance literature:: 3,5-(bistrifluoromethyl)chlorobenzene; With magnesium; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere; Schlenk technique;

With phosphonic acid diethyl ester; In tetrahydrofuran; at 20 ℃; for 2.25h; Inert atmosphere; Schlenk technique; Cooling with ice;
DOI:10.1021/ja509381w