328-72-3

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE
• Synonyms: 5-chloro-1,3-bis(trifluoromethyl)-benzene;benzene,5-chloro-1,3-bis(trifluoromethyl)-;bistrifluoromethylchlorobenzene;1-CHLORO-3,5-BIS(TRIFLUOROMETHYL)BENZENE;3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE;3,5-BIS(TRIFLUOROMETHYL)-1-CHLOROBENZENE;3,5-Bis(trifluoromethyl)chlorobenzene 97%;3,5-Bis(trifluoromethyl)chlorobenzene97%
• CAS NO: 328-72-3
• Molecular Formula: C₈H₃ClF₆
• Molecular Weight: 248.55
• Product Categories: Miscellaneous
• Mol File: 328-72-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: -25 °C
• Boiling Point: 133.78°C (rough estimate)
• Flash Point: 42.7 °C
• Appearance: /
• Density: 1.475 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(328-72-3)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE(328-72-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 328-72-3(Hazardous Substances Data)

Usage

Description

3,5-Bis(trifluoromethyl)chlorobenzene is a chemical compound characterized by a benzene ring with two trifluoromethyl groups and a chlorine atom attached at the 3 and 5 positions. This colorless liquid is known for its chemical stability and hydrophobicity, conferred by the trifluoromethyl groups, and is utilized in various applications due to its unique properties. It is important to handle this compound with care, as it can be harmful if ingested, inhaled, or cause irritation to the skin and eyes.

Uses

Used in Organic Synthesis:
3,5-Bis(trifluoromethyl)chlorobenzene is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, contributing to the development of new materials and specialty chemicals.
Used in Chemical Reactions:
In the chemical industry, 3,5-Bis(trifluoromethyl)chlorobenzene is utilized as a solvent and reagent, taking advantage of its unique properties to facilitate various chemical processes.
Used in the Development of New Materials:
3,5-BIS(TRIFLUOROMETHYL)CHLOROBENZENE's high level of chemical stability and hydrophobicity make it a valuable component in the creation of innovative materials and specialty chemicals, enhancing their performance and applicability in different fields.

Upstream product

• 402-31-3 1,3-bis(trifluoromethyl)benzene 
• 7647-18-9 antimonypentachloride 
• 7782-50-5 chlorine 
• 881-99-2 1,3-bis-trichloromethyl-benzene 
• 121-91-5 isophthalic acid 

Downstream Products

• 1579-63-1 (3,5-bis-trifluoromethyl-phenyl)-dichloro-methyl-silane 
• 705250-77-7 3-[3,5-bis(trifluoromethyl)phenyl]-2(Z)-propenoic acid methyl ester 
• 166172-69-6 bis(3,5-bis(trifluoromethyl)phenyl)phosphine 
• 15979-14-3 bis[3,5-bis(trifluoromethyl) phenyl]phosphine oxide 
• 69807-91-6 2-(3,5-bis-trifluoromethyl-phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane 
• 289686-70-0 α,α-Dimethyl-3,5-bis(trifluoromethyl)benzeneacetic Acid 
• 85068-32-2 3,5-bis(trifluoromethyl)phenylacetonitrile 
• 1027717-63-0 3,5-bis(trifluoromethyl)cinnamonitrile 
• 27126-93-8 3,5-bis(trifluoromethyl)benzonitrile 
• 368-67-2 3,5-bis-trifluoromethyl-phenetole 
• 349-60-0 1-methoxy-3,5-bis(trifluoromethyl)benzene 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ORGANIC HALIDES

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

Process for preparing chlorinated compounds

A process for the preparation of monochlorinated and dichlorinated bis-(perhalomethyl)-benzenes of the formula (I) by reacting bis-(perhalomethyl)-benzenes of the formula (II) with elementary chlorine in chlorosulfonic acid as the reaction medium, at a te