N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

Base Information

Chemical Name:N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide
CAS No.:1426083-88-6
Molecular Formula:C₂₁H₃₄FNO₃
Molecular Weight:367.504
Hs Code.:

Synonyms:N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

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Chemical Property of N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

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Technology Process of N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

There total 11 articles about N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1426083-87-5
diethyl 2-acetamido-2-[4-(8-fluorooctyl)phenethyl]malonate

: 1426083-88-6
N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

Guidance literature:: With lithium borohydride; ethanol; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/jm502021d

Reference yield:

: 1426083-87-5
diethyl 2-acetamido-2-[4-(8-fluorooctyl)phenethyl]malonate

: 1426083-88-6
N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

: 1426083-89-7
C₂₀H₃₂FNO₂

Guidance literature:: With lithium borohydride; In tetrahydrofuran; ethanol; at 0 - 20 ℃; Overall yield = 13mg;

Reference yield:

: 1068-90-2
2-acetylaminomalonic acid diethyl ester

: 1426083-88-6
N-{4-[4-(8-fluorooctyl)phenyl]-1-hydroxy-2-(hydroxymethyl)-butan-2-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 5 h / Reflux

2: Nonafluorobutanesulfonyl fluoride; N-ethyl-N,N-diisopropylamine; triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 48 h / 20 °C

3: triethylsilane; palladium dichloride / ethanol / 20 - 98 °C / Inert atmosphere

4: lithium borohydride; ethanol / tetrahydrofuran / 0 - 20 °C

With triethylsilane; lithium borohydride; ethanol; Nonafluorobutanesulfonyl fluoride; caesium carbonate; triethylamine tris(hydrogen fluoride); N-ethyl-N,N-diisopropylamine; palladium dichloride; In tetrahydrofuran; ethanol; acetonitrile;