Technology Process of latamoxef disodium
There total 9 articles about latamoxef disodium which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C49H46N6O11S;
With
aluminum (III) chloride;
In
dichloromethane;
at -35 - -25 ℃;
for 2h;
Large scale;
With
hydrogenchloride;
In
water; ethyl acetate;
pH=1.2;
Large scale;
With
sodium hydrogencarbonate;
In
water; ethyl acetate;
pH=5.8;
Large scale;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: pyridine; trichlorophosphate / dichloromethane / 0.5 h / -25 °C / Inert atmosphere
1.2: 0.17 h / -10 °C / Inert atmosphere
1.3: 1 h / 20 °C / Inert atmosphere
2.1: 3 h / 50 °C
3.1: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 °C / Inert atmosphere
With
pyridine; methoxybenzene; trifluoroacetic acid; trichlorophosphate;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 3 h / 50 °C
2: trifluoroacetic acid; methoxybenzene / dichloromethane / 2 h / 0 °C / Inert atmosphere
With
methoxybenzene; trifluoroacetic acid;
In
dichloromethane;