66510-99-4

Basic information

• Product Name: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester
• Synonyms: (6R,7R)-7-Amino-7-methoxy-3-[(1-methyl-1H-tetrazol-5-ylthio)methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid diphenylmethyl ester;(6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester;LataMoxef SodiuM InterMediate 2;(6R,7R)-Benzhydryl 7-amino-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)-thio)methyl)-8-oxo-5-oxa-1-a;(6R,7R)-Benzhydryl 7-amino-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)-thio)methyl)-8-oxo-5-oxa-;Intermediate 2 of Latamoxef Sodium;RJBJKWDIIMRLDA-ZBQDIEFISA-N
• CAS NO: 66510-99-4
• Molecular Formula: C₂₄H₂₄N₆O₅S
• Molecular Weight: 508.56
• EINECS: 1533716-785-6
• Mol File: 66510-99-4.mol

Chemical Properties

• Boiling Point: 723.6±70.0 °C(Predicted)
• Appearance: /
• Density: 1.49
• Storage Temp.: 2-8°C
• PKA: 2.85±0.60(Predicted)
• CAS DataBase Reference: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(66510-99-4)
• EPA Substance Registry System: (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester(66510-99-4)

Safety Data

• Hazardous Substances Data: 66510-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester is used as a potential antibiotic agent for its possible role in combating bacterial infections. The β-lactam core and the amino group present in the compound may contribute to its antibacterial activity, although further studies are needed to confirm its efficacy and safety.
Used in Research and Development:
In the field of scientific research, (6β)-3-(1-Methyl-1H-tetrazole-5-ylthiomethyl)-7α-amino-7-methoxy-8-oxo-5-oxa-1-azabicyclo[4.2.0]octa-2-ene-2-carboxylic acid benzhydryl ester serves as a subject for exploration and experimentation. Researchers may investigate its chemical properties, potential interactions with biological systems, and its capacity for drug development. The presence of multiple functional groups provides a basis for studying its reactivity and potential modifications to enhance its pharmacological profile.

Upstream product

• 66429-65-0 (6R)-7t-amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 96855-19-5 7-amino-3-chloromethyl-1-oxa-3-cephem-4-carboxylic acid diphenyl ester 
• 51138-06-8 sodium 1-methyl-1H-tetrazole-5-thiolate 
• 68402-51-7 (6R,7R)-7-Benzoylamino-3-chloromethyl-7-methoxy-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzyl ester 
• 68402-81-3 diphenylmethyl 7β-benzamido-7α-methoxy-3-<<(1-methyl-1H-yetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate 
• 66364-50-9 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate 

Downstream Products

• 66364-50-9 diphenylmethyl 7β-(phenylacetamido)-7α-methoxy-3-<<(1-methyl-1H-tetrazol-5-yl)thio>methyl>-1-oxadethia-3-cephem-4-carboxylate 
• 206854-99-1 (6R,7R)-7-Methoxy-7-(2-methoxy-benzoylamino)-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 206855-16-5 (6R,7R)-7-Methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-7-(2-propoxy-benzoylamino)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 66429-65-0 (6R)-7t-amino-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 86862-88-6 (6R,7R)-7-[2-(4-Benzyloxycarbonyloxy-phenyl)-acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 73955-48-3 (R)-7,7-dihydroxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 70371-38-9 (6R)-7t-((R)-2-formyloxy-2-phenyl-acetylamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 1079440-87-1 moxalactam 
• 70653-54-2 C₄₁H₃₈N₆O₁₀S 
• 76858-80-5 latamoxef disodium 

Relevant articles and documents

Synthesis method of cefamoxef sodium

The invention relates to a synthesis method of latamoxef sodium. The synthesis method specifically comprises the following steps: reacting an oxygen cephalosporin mother nucleus 1 with 1-methyl-5-mercaptotetrazole sodium salt to obtain a compound 2, carrying out deprotection to obtain a compound 3, adding methoxyl and a 7-site side chain on the compound 3 to obtain a compound 5, and then, carryingout final deprotection on the compound 5 to obtain high-purity latamoxef sodium. The method provided by the invention is high in yield, mild in condition and environment-friendly; enzyme is used fordeprotection and condensation reaction, so that high-toxicity and high-corrosivity reagents are avoided; and the high-purity latamoxef sodium is obtained at a high yield.

METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND

The present disclosure provides a method for preparing a 7α-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solv

7 β-amino -7 α-methoxy-3-cephem compound preparation method

The invention relates to a preparation method of a medical raw material 7beta-amino-7lapha-methoxy-3-cephem compound. Methods in prior arts have the problems of more steps and low yield. According to the 7beta-amino-7lapha-methoxy-3-cephem compound preparation method provided by the invention, a beta-lactam compound is adopted as a raw material, and is subjected to a reaction with bis(trichloromethyl)carbonate under the existence of an organic alkali, such that a iminochloride-beta-lactam compound is produced; methanol is added for alcoholysis, such that the 7beta-amino-7lapha-methoxy-3-cephem compound is produced. The method provided by the invention has the advantages of mild and easy-to-control reaction conditions, high yield, no product of 7alpha-methoxy-7beta-amino-3-cephem compound isomer, and easy separation. With the method, the 7beta-amino-7lapha-methoxy-3-cephem compound product with ultrahigh purity can be obtained.

PROCESS FOR THE PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES AND RELATED INTERMEDIATES

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