Technology Process of C44H57N11O8S2
There total 11 articles about C44H57N11O8S2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
nitrolexitropsin;
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 2h;
under 2585.74 Torr;
(E)-3-[2-[(5S)-5-[bis(ethylthio)methyl]-1-(2-nitrobenzoyl)-tetrahydro-1H-3-pyrrolyliden]-acetamido]propionic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
DOI:10.1515/HC.2002.8.2.115
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: SOCl2 / benzene
2.1: H2SO4
3.1: DIBAL-H
4.1: TMSCl
5.1: 60 percent / Ac2O-DMSO
6.1: 80 percent / benzene
7.1: 90 percent / 1N NaOH
8.1: 70 percent / EDCI; HOBT; NaHCO3 / dimethylformamide / 12 h
9.1: 90 percent / 1N NaOH / methanol / 40 - 50 °C
10.1: H2 / 10 percent Pd/C / methanol / 2 h / 2585.74 Torr
10.2: 60 percent / EDCI; HOBT / dimethylformamide / 12 h / 20 °C
With
sodium hydroxide; chloro-trimethyl-silane; thionyl chloride; sulfuric acid; hydrogen; acetic anhydride; diisobutylaluminium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; benzene;
7.1: Wittig reaction;
DOI:10.1515/HC.2002.8.2.115
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: H2SO4
2.1: DIBAL-H
3.1: TMSCl
4.1: 60 percent / Ac2O-DMSO
5.1: 80 percent / benzene
6.1: 90 percent / 1N NaOH
7.1: 70 percent / EDCI; HOBT; NaHCO3 / dimethylformamide / 12 h
8.1: 90 percent / 1N NaOH / methanol / 40 - 50 °C
9.1: H2 / 10 percent Pd/C / methanol / 2 h / 2585.74 Torr
9.2: 60 percent / EDCI; HOBT / dimethylformamide / 12 h / 20 °C
With
sodium hydroxide; chloro-trimethyl-silane; sulfuric acid; hydrogen; acetic anhydride; diisobutylaluminium hydride; sodium hydrogencarbonate; benzotriazol-1-ol; dimethyl sulfoxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; benzene;
6.1: Wittig reaction;
DOI:10.1515/HC.2002.8.2.115
