(4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

Base Information

• Chemical Name: (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate)
• CAS No.: 221298-01-7
• Molecular Formula: C₂₁H₂₀BrNO₆S₂
• Molecular Weight: 526.429
• Mol file: 221298-01-7.mol

Synonyms:(4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

Chemical Property of (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate)

There total 6 articles about (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-bromo-2,6-pyridinedimethanol (120491-88-5) + p-toluenesulfonyl chloride (98-59-9) → (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate) (221298-01-7)

Guidance literature:

With potassium hydroxide; In dichloromethane; water; at 0 - 20 ℃;

DOI:10.3998/ark.5550190.0012.906

Reference yield: 77.0%

toluene-p-sulfonyl bromide (1950-69-2) + 4-bromo-2,6-pyridinedimethanol (120491-88-5) → (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate) (221298-01-7)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 17h;

DOI:10.1039/a901941c

Reference yield:

dimethyl 4-bromo-2,6-pyridinedicarboxylate (162102-79-6) → (4-bromopyridine-2,6-diyl)bis(methylene) bis(4-methylbenzenesulfonate) (221298-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / ethanol

2: 81 percent / KOH / CH₂Cl₂; H₂O / 0 °C

With potassium hydroxide; sodium tetrahydroborate; In ethanol; dichloromethane; water;

DOI:10.1021/jo0301393

upstream raw materials:

toluene-p-sulfonyl bromide

4-bromo-2,6-pyridinedimethanol

p-toluenesulfonyl chloride

dimethyl 4-bromo-2,6-pyridinedicarboxylate

Downstream raw materials:

dimethyl 5-{5-[3,6,9,12-tetraoxa-18-azabicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-trien-16-yl]-2-thienyl}isophthalate