Indolin-5-amine

Base Information

• Chemical Name: Indolin-5-amine
• CAS No.: 15918-80-6
• Molecular Formula: C8H10 N2
• Molecular Weight: 134.181
• DSSTox Substance ID: DTXSID101309309
• Mol file: 15918-80-6.mol

Synonyms:indolin-5-amine;2,3-dihydro-1H-indol-5-amine;15918-80-6;1H-Indol-5-amine,2,3-dihydro-(9CI);5-aminoindoline;SCHEMBL1880170;CNSBIJRLKLHUIQ-UHFFFAOYSA-N;2,3-dihydro-1H-indol-5-ylamine;DTXSID101309309;MFCD09035713;STK504516;AKOS000266499;SB64390;BS-27694;CS-0206029;FT-0744304;EN300-338929;A903020

Chemical Property of Indolin-5-amine

Chemical Property:

• Melting Point: 678.5 °C
• Boiling Point: 323.2±31.0 °C(Predicted)
• PKA: 7.13±0.20(Predicted)
• PSA: 38.05000
• Density: 1.148±0.06 g/cm3(Predicted)
• LogP: 1.95600
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 134.084398327
• Heavy Atom Count: 10
• Complexity: 124

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dihydro-1H-indol-5-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CNC2=C1C=C(C=C2)N

Technology Process of Indolin-5-amine

There total 5 articles about Indolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 5-amino indoline (15918-80-6)

Guidance literature:

Reference yield: 52.0%

1-(5-aminoindolin-1-yl)ethanone (4993-96-8) → 5-amino indoline (15918-80-6)

Guidance literature:

With hydrogenchloride;

Reference yield:

5-nitro-2,3-dihydro-1H-indole (32692-19-6) → 5-amino indoline (15918-80-6)

Guidance literature:

With methanol; nickel; hydrazine hydrate;

upstream raw materials:

5-nitro-2,3-dihydro-1H-indole

1-(5-aminoindolin-1-yl)ethanone

1-indoline

1-(5-nitro-2,3-dihydroindol-1-yl)ethanone

Downstream raw materials:

(2,3-dihydro-1H-indol-5-yl)-carbamic acid phenyl ester

Refernces

• 1、 Salekh, M. A.,Krasavina, L. S.,Vigdorchik, M. M.,Turchin, K. F.,Sapukova, A. A.,et al.. "N-GLUCOSYLATION OF AMINOINDOLINES AND THE BISGLUCOSIDES OF 5-AMINOINDOLE". . p. 2348 - 2355. Retrieved 2007/10/02.