N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide
CAS No.:1602922-88-2
Molecular Formula:C₂₀H₂₃NO₃S
Molecular Weight:357.474
Hs Code.:

Synonyms:N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

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Chemical Property of N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

There total 1 articles about N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 60736-71-2
3-methyl-4-methoxybenzyl chloride

: 161040-05-7
N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide

: 1602922-88-2
N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

Guidance literature:: N-(but-3-yn-1-yl)-4-methylbenzenesulfonamide; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h;

3-methyl-4-methoxybenzyl chloride; With tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; mineral oil; at 60 ℃;
DOI:10.1021/jo500308y

Reference yield: 23.0%

: 1602922-88-2
N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

: 94532-99-7
N-(2-formylphenyl)methanesulfonamide

: 1602922-94-0
N-(5-hydroxy-5-(2-(methylsulfonamido)phenyl)pent-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

Guidance literature:: N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.5h;

N-(2-formylphenyl)methanesulfonamide; In tetrahydrofuran; at -78 ℃; for 0.5h;
DOI:10.1021/jo500308y

Reference yield:

: 1602922-88-2
N-(but-3-yn-1-yl)-N-(4-methoxy-3-methylbenzyl)-4-methylbenzenesulfonamide

: 1602922-48-4
4a-(4-methoxy-3-methylphenyl)-5-(methylsulfonyl)-2-tosyl-1,2,3,4,4a,5-hexahydrobenzo[b][1,6]naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 0 °C

With n-butyllithium; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo500308y