2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile
• CAS No.: 910487-62-6
• Molecular Formula: C₁₇H₁₄N₄OS
• Molecular Weight: 322.39
• Mol file: 910487-62-6.mol

Synonyms:2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

Chemical Property of 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile

There total 2 articles about 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-(phenylthio)pyridine-3,5-dicarbonitrile → 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile (910487-62-6)

Guidance literature:

With sodium salt; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.ejmech.2018.02.081

Reference yield:

4-(cyclopropylmethoxy)benzaldehyde (164520-99-4) → 2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile (910487-62-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol; water / 55 °C

2: sodium salt / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2018.02.081

Reference yield: 87.0%

2-amino-4-[4-(cyclopropylmethoxy)phenyl]-6-mercaptopyridine-3,5-dicarbonitrile (910487-62-6) → 2-amino-6-{[(2-aminothiazol-4-yl)methyl]thio}-4-[4-(cyclopropylmethoxy)phenyl]pyridine-3,5-dicarbonitrile

Guidance literature:

With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.ejmech.2018.02.081

upstream raw materials:

4-(cyclopropylmethoxy)benzaldehyde

Downstream raw materials:

2-{[4-(4-acetamidophenyl)-6-amino-3,5-dicyanopyridin-2-yl]thio}acetamide