-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

Base Information

Chemical Name:-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid
CAS No.:151858-78-5
Molecular Formula:C₁₄H₁₇NO₅
Molecular Weight:279.293
Hs Code.:

<R(Z)>-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

Synonyms:-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

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Chemical Property of -4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

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Technology Process of -4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

There total 7 articles about -4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108-31-6
maleic anhydride

: 151858-75-2
(2R)-2-amino-2-(2-methoxy-6-methylphenyl)ethyl alcohol

: 151858-78-5
-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

Guidance literature:: In diethyl ether; for 20h; Ambient temperature;
DOI:10.1021/ja00076a036

Reference yield:

: 151858-71-8
(2-methoxy-6-methylphenyl)acetic acid

: 151858-78-5
-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 0 deg C, 45 min

2: 1.) n-BuLi / 1.) THF, -78 deg C, 15 min, 2.) THF, a) -78 deg C, 15 min, b) RT, 9 h

3: 1.) KN(SiMe₃)2, 2.) trisyl azide, 3.) AcOH

4: 83 percent / NaBH₄ / tetrahydrofuran; H₂O / 42 h / 5 °C

5: 78 percent / H₂ / 10percent Pd/C / ethanol / 24 h / Ambient temperature

6: 80 percent / diethyl ether / 20 h / Ambient temperature

With sodium tetrahydroborate; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; potassium hexamethylsilazane; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; water;
DOI:10.1021/ja00076a036

Reference yield:

: 151858-74-1
(2R)-2-azido-2-(2-methoxy-6-methylphenyl)ethanol

: 151858-78-5
-4-<<2-hydroxy 1-(2-methoxy-6-methylphenyl)ethyl>amino>-4-oxo-2-butenoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / H₂ / 10percent Pd/C / ethanol / 24 h / Ambient temperature

2: 80 percent / diethyl ether / 20 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In diethyl ether; ethanol;
DOI:10.1021/ja00076a036