tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Base Information

Chemical Name:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate
CAS No.:853069-52-0
Molecular Formula:C₂₉H₃₁ClN₆O₃
Molecular Weight:547.057
Hs Code.:

Synonyms:tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Chemical Property of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

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Technology Process of tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

There total 7 articles about tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 853069-53-1
tert-butyl {(3R)-1-[7-carbamoyl-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

: 853069-52-0
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: tert-butyl {(3R)-1-[7-carbamoyl-3-(2-chlorobenzyl)-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate; With trifluoroacetic anhydride; In tetrahydrofuran; at 20 - 65 ℃; for 3h;

With potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853070-08-3
C₂₉H₃₃ClIN₅O₅

: 853069-52-0
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

3.1: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

4.1: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

5.1: ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

6.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 - 65 °C

6.2: 3 h / 20 °C

With hydrogenchloride; ammonium hydroxide; silver (I) hydrogen carbonate; palladium diacetate; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046

Reference yield:

: 853069-86-0
methyl 3-[{[2-{(3R)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-1-(2-chlorobenzyl)-4-iodo-1H-imidazol-5-yl]carbonyl}(methyl)amino]benzoate

: 853069-52-0
tert-butyl {(3R)-1-[3-(2-chlorobenzyl)-7-cyano-5-methyl-4-oxo-4,5-dihydro-3H-imidazo[4,5-c]quinolin-2-yl]piperidin-3-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: silver (I) hydrogen carbonate; palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 1 h / 150 °C

2.1: hydrogenchloride / 1,4-dioxane / 4 h / 80 °C

3.1: sodium hydrogencarbonate / tetrahydrofuran; water / 3 h / 20 °C

4.1: ammonium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C

5.1: trifluoroacetic anhydride / tetrahydrofuran / 3 h / 20 - 65 °C

5.2: 3 h / 20 °C

With hydrogenchloride; ammonium hydroxide; silver (I) hydrogen carbonate; palladium diacetate; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; triphenylphosphine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.07.046