3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

Base Information

Chemical Name:3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide
CAS No.:956234-94-9
Molecular Formula:C₂₉H₄₃N₃O₅
Molecular Weight:513.678
Hs Code.:

Synonyms:3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

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Chemical Property of 3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

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Technology Process of 3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

There total 10 articles about 3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 956234-92-7
3-[[(13R)-13-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-15,15,16,16-tetramethyl-4,14-dioxa-11-aza-15-silaheptadec-1-yl](methyl)amino]benzamide

: 956234-94-9
3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

Guidance literature:: With TBAF on silica gel; In tetrahydrofuran; at 20 ℃; for 42h;

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 956234-94-9
3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium hydroxide / tetrabutylammomium bromide / water / 20 h / 20 °C

2: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

3: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

4: triethylamine / dichloromethane / 20 °C

5: N-ethyl-N,N-diisopropylamine / 5 h / 120 °C

6: hydrazine / ethanol / 22 h / 20 °C

7: potassium carbonate / 1,4-dioxane / 39.5 h / 20 - 105 °C

8: TBAF on silica gel / tetrahydrofuran / 42 h / 20 °C

With sodium hydroxide; TBAF on silica gel; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; tetrabutylammomium bromide; cetyltributylphosphonium bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 956234-76-7
({3-[(6-bromohexyl)oxy]propoxy}methyl)benzene

: 956234-94-9
3-[{3-[(6-{[(2R)-2-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)-2-hydroxyethyl]amino}hexyl)oxy]propyl}(methyl)amino]benzamide

Guidance literature:: Multi-step reaction with 7 steps

1: cetyltributylphosphonium bromide / N,N-dimethyl-formamide / 20 - 75 °C

2: hydrogen / palladium 10% on activated carbon / methanol; ethyl acetate / 4 h / 20 °C / 1965.2 Torr

3: triethylamine / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine / 5 h / 120 °C

5: hydrazine / ethanol / 22 h / 20 °C

6: potassium carbonate / 1,4-dioxane / 39.5 h / 20 - 105 °C

7: TBAF on silica gel / tetrahydrofuran / 42 h / 20 °C

With TBAF on silica gel; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; hydrazine; palladium 10% on activated carbon; cetyltributylphosphonium bromide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;