(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

Base Information

Chemical Name:(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol
CAS No.:129413-15-6
Molecular Formula:C₃₁H₄₂O₃Si
Molecular Weight:490.758
Hs Code.:

Synonyms:(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

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Chemical Property of (2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

Chemical Property:

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Technology Process of (2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

There total 1 articles about (2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129446-67-9
(2R,3R,4S,5S,6S)-2-Methoxy-3,5,6-trimethyl-tetrahydro-pyran-4-ol

: 100-39-0
benzyl bromide

: 58479-61-1
tert-butylchlorodiphenylsilane

: 129413-15-6
(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

Guidance literature:: Yield given. Multistep reaction;
DOI:10.1016/S0040-4039(00)94609-4

Reference yield: 99.0%

: 129413-15-6
(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

: 129413-16-7
(3S,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-one

Guidance literature:: With MS 3A; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)94609-4

Reference yield:

: 129413-15-6
(2S,3R,4R,5S)-4-Benzyloxy-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexan-2-ol

: C₃₆H₃₈O₅

Guidance literature:: Multi-step reaction with 10 steps

1: 99 percent / MS 3A / CH₂Cl₂ / Ambient temperature

2: tetrahydrofuran / 67 h / Ambient temperature

3: n-butyllithium / hexane; tetrahydrofuran / 2 h / Ambient temperature

4: 1.) O₃ 2.) (MeO)3P / 1.) MeOH, -78 deg C, 1min

5: toluene / 1.5 h / -78 °C

6: NaH / dimethylformamide

7: n-Bu₄NF / tetrahydrofuran

8: Swern oxidation

9: NaClO₂/NH₂SO₃H / dioxane; H₂O

10: Et₃N / tetrahydrofuran

With sodium chlorite; n-butyllithium; aminosulfonic acid; tetrabutyl ammonium fluoride; sodium hydride; ozone; triethylamine; phosphorous acid trimethyl ester; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(00)94609-4