4-Hydrazinoquinoline

Base Information

• Chemical Name: 4-Hydrazinoquinoline
• CAS No.: 15793-93-8
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID50427248
• Nikkaji Number: J2.421.426E
• Wikidata: Q82239945
• Mol file: 15793-93-8.mol

Synonyms:4-Hydrazinoquinoline;15793-93-8;4-hydrazinylquinoline;quinolin-4-ylhydrazine;Quinoline, 4-hydrazinyl-;(4e)-4-Hydrazinylidene-1,4-Dihydroquinoline;Quinoline-4-ylhydrazine;SCHEMBL248690;SCHEMBL8521262;QUINOLIN-4-YL-HYDRAZINE;DTXSID50427248;MYGFXCLXHGITIQ-UHFFFAOYSA-N;MFCD00272468;AKOS002683769;AB05747;2-(perfluoro-3-methylbutyl)ethylmethacrylate;BB 0241268;CS-0258502;FT-0618610;EN300-70327;F2183-1107;7VS

Chemical Property of 4-Hydrazinoquinoline

Chemical Property:

• Vapor Pressure: 5.1E-06mmHg at 25°C
• Refractive Index: 1.758
• Boiling Point: 381.4 °C at 760 mmHg
• Flash Point: 184.4 °C
• PSA: 54.17000
• Density: 1.29 g/cm³
• LogP: 1.64260
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 159.079647300
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

98%min ^*data from raw suppliers

4-HYDRAZINOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC=N2)NN
• Uses: 4-Hydrazinylquinoline is used as a reactant in the preparation of tuberculostatic quinolylhydrazones.

Technology Process of 4-Hydrazinoquinoline

There total 5 articles about 4-Hydrazinoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

4-methoxyquinoline (607-31-8) → 4-hydrazineylquinoline (15793-93-8)

Guidance literature:

With hydrazine hydrate; In ethanol; for 16h; Reflux;

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) → 4-hydrazineylquinoline (15793-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 12 h / 80 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 775.74 Torr

3: hydrazine hydrate / ethanol / 16 h / Reflux

With palladium 10% on activated carbon; hydrogen; hydrazine hydrate; In methanol; ethanol;

Reference yield:

7-chloro-4-methoxyquinoline (26707-52-8) → 4-hydrazineylquinoline (15793-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 16 h / 20 °C / 775.74 Torr

2: hydrazine hydrate / ethanol / 16 h / Reflux

With palladium 10% on activated carbon; hydrogen; hydrazine hydrate; In methanol; ethanol;

upstream raw materials:

4-chloroquinoline

4,7-dichloroquinoline

7-chloro-4-methoxyquinoline

4-methoxyquinoline

Downstream raw materials:

2-(1H-pyrazol-3-yl)aniline

tert-Butyl (5-methyl-3-phenyl-1-quinolin-4-yl-1H-pyrazol-4-yl)acetate

2-(4-cyanobenzylidene)-1-(quinolin-4-yl)hydrazine

2-(4-nitrobenzylidene)-1-(quinolin-4-yl)hydrazine

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS". . . Retrieved 2018/07/05.