(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Base Information

Chemical Name:(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine
CAS No.:1345731-55-6
Molecular Formula:C₁₈H₁₇Cl₂NO₂
Molecular Weight:350.244
Hs Code.:

Synonyms:(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

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Chemical Property of (3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

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Technology Process of (3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

There total 4 articles about (3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1345731-82-9
(3R,5S)-7-chloro-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

: 122-01-0
4-chloro-benzoyl chloride

: 1345731-55-6
(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 1450-74-4
5-chloro-2-hydroxyacetophenone

: 1345731-55-6
(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / toluene / 68 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3: sodium tetrahydroborate / ethanol / 0 - 20 °C

4: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 1345731-80-7
tert-butyl [(R)-2-(2-acetyl-4-chlorophenoxy)-1-methylethyl]carbamate

: 1345731-55-6
(3R,5S)-7-chloro-4-(4-chlorobenzoyl)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: sodium tetrahydroborate / ethanol / 0 - 20 °C

3: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With sodium tetrahydroborate; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.08.093