(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

Base Information

Chemical Name:(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate
CAS No.:1253587-29-9
Molecular Formula:C₂₂H₂₆O₆
Molecular Weight:386.445
Hs Code.:

Synonyms:(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

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Chemical Property of (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

Chemical Property:

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Technology Process of (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

There total 6 articles about (6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1253587-35-7
(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-benzyloxybenzoate

: 1253587-29-9
(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jf102287h

Reference yield:

: 121-34-6
3-methoxy-4-hydroxybenzoic acid

: 1253587-29-9
(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 15 h / Inert atmosphere

2: potassium hydroxide / Reflux

3: dmap; dicyclohexyl-carbodiimide / dichloromethane / 15 h / 20 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h / 20 °C

With dmap; palladium 10% on activated carbon; hydrogen; potassium carbonate; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Steglich esterification;
DOI:10.1021/jf102287h

Reference yield:

: 64338-22-3
benzyl 6-(benzyloxy)-2,5,7,8-tetramethylchroman-2-carboxylate

: 1253587-29-9
(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methyl 3-methoxy-4-hydroxybenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 15 h / 20 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / tetrahydrofuran / 24 h / 20 °C

With dmap; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; 2: Steglich esterification;
DOI:10.1021/jf102287h