Technology Process of 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal
There total 2 articles about 12,13-de-epoxy-12,13-didehydrorosamicin 20-dimethyl acetal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; titanium(III) chloride;
In
methanol; water;
at 0 ℃;
for 3h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
pH 1.0;
DOI:10.1039/P19890000787
- Guidance literature:
-
With
hydrogenchloride; titanium(III) chloride;
In
methanol; water;
at 0 ℃;
for 0.33h;
Yield given. Yields of byproduct given. Title compound not separated from byproducts;
pH 1.5;
DOI:10.1039/P19890000787
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / MCPBA, disodium hydrogen phosphate / CH2Cl2 / 19 h / 25 °C / further reaction time
2: 75 percent / aq. 0.1M hydrochloric acid / H2O / 0.75 h / 25 °C
3: 71 percent / triphenylphosphine / CH2Cl2 / 71 h / 55 °C / further reagent
With
hydrogenchloride; disodium hydrogenphosphate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
dichloromethane; water;
DOI:10.1039/P19890000787
