N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Base Information

Chemical Name:N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester
CAS No.:128718-63-8
Molecular Formula:C₄₄H₅₅N₇O₁₀S
Molecular Weight:874.028
Hs Code.:

Synonyms:N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Suppliers and Price of N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

There total 10 articles about N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2448-45-5
Cbz-D-Phe

: 128718-63-8
N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

2: 74.5 percent / hydrazine / methanol / Ambient temperature

3: HCl, t-butylnitrite / dimethylformamide; dioxane / 0.08 h / -20 °C

4: Et₃N / dimethylformamide; dioxane / 16 h / 4 °C

With hydrogenchloride; tert.-butylnitrite; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 5680-80-8
methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride

: ((R)-1-{(R)-2-(Acetylamino-methylsulfanyl)-1-[(R)-1-((S)-1-azidocarbonyl-3-methyl-butylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-ethylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester

: 128718-63-8
N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; at 4 ℃; for 16h; Yield given;

Reference yield:

: 7517-19-3
methyl (L)-leucinate hydrochloride

: 128718-63-8
N-benzyloxycarbonyl-D-phenylalanyl-L-cysteinyl(Acm)-D-tryptophyl-L-leucyl-L-serine methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 85.9 percent / dicyclohexylcarbodiimide (DCCI), 1-hydroxybenzotriazole (HOBt), Et₃N / dimethylformamide / 4 °C

2: 83.6 percent / 6N HCl, dithioethane / ethyl acetate / 1 h

3: 89.7 percent / Et₃N / dimethylformamide / Ambient temperature

4: 3N HCl / ethyl acetate

5: 83 percent / Et₃N, 1-hydroxybenzotriazole (HOBt), dicyclohexylcarbodiimide (DCCI) / dimethylformamide / 4 °C

6: 74.5 percent / hydrazine / methanol / Ambient temperature

7: HCl, t-butylnitrite / dimethylformamide; dioxane / 0.08 h / -20 °C

8: Et₃N / dimethylformamide; dioxane / 16 h / 4 °C

With hydrogenchloride; tert.-butylnitrite; benzotriazol-1-ol; ethane-1,2-dithiol; triethylamine; dicyclohexyl-carbodiimide; hydrazine; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide;