(3S,4R)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Base Information

Chemical Name:(3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline
CAS No.:143378-40-9
Molecular Formula:C₃₃H₃₅NO₃Si
Molecular Weight:521.731
Hs Code.:

Synonyms:(3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Suppliers and Price of (3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

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Technology Process of (3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

There total 2 articles about (3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143377-85-9
2-(tert-Butyl-diphenyl-silanyloxy)-2-(3,4-dimethoxy-phenyl)-1-phenyl-ethylamine; hydrochloride

: 143378-40-9
(3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 0.33 h / 150 °C

2: PCl₅ / CH₂Cl₂ / 3 h / Ambient temperature; cyclization reaction: other reagents, other solvents, or with other substituted amides

With phosphorus pentachloride; In dichloromethane;
DOI:10.1016/S0040-4020(01)80450-6

Reference yield:

: 143378-38-5
N-<2-(3,4-dimethoxyphenyl)-1-phenyl-2-(tert-butyldiphenylsilyloxy)ethyl>formamide

: 24285-10-7
6,7-dimethoxy-3-phenylisoquinoline

: 143378-40-9
(3S*,4R*)-6,7-dimethoxy-3-phenyl-4-(tert-butyldiphenylsilyloxy)-3,4-dihydroisoquinoline

Guidance literature:: With phosphorus pentachloride; In dichloromethane; for 3h; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/S0040-4020(01)80450-6