Technology Process of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[(2-methoxyethyl)(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide
There total 9 articles about N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-7-(3-{[(2-methoxyethyl)(methyl)amino]carbonyl}phenyl)-1-benzothiophene-2-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1,4-dioxane; water
2: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C
3: hydrogenchloride / water; acetonitrile
With
hydrogenchloride; potassium acetate; sodium carbonate; bis(pinacol)diborane;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; DMF (N,N-dimethyl-formamide); water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C
2: hydrogenchloride / water; acetonitrile
With
hydrogenchloride; potassium acetate; sodium carbonate; bis(pinacol)diborane;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
DMF (N,N-dimethyl-formamide); water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: sodium hydride
2: 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide)
3: 1,4-dioxane; water
4: potassium acetate; sodium carbonate; bis(pinacol)diborane / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / DMF (N,N-dimethyl-formamide); water / 36 h / 60 - 90 °C
5: hydrogenchloride / water; acetonitrile
With
hydrogenchloride; 2-(7-aza-1H-benzotriazol-1-yl)-1,1,3,3-tetratetramethyluronium hexafluorophosphate; potassium acetate; sodium hydride; sodium carbonate; N-ethyl-N,N-diisopropylamine; bis(pinacol)diborane;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
1,4-dioxane; DMF (N,N-dimethyl-formamide); water; acetonitrile;