Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Base Information

• Chemical Name: Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine
• CAS No.: 81244-12-4
• Molecular Formula: C₆H₁₅N*C₆₂H₆₀N₅O₁₀PS
• Molecular Weight: 1199.42

Synonyms:Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Chemical Property of Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

There total 8 articles about Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester (81244-08-8) + triethylamine (121-44-8) → Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (81244-12-4)

Guidance literature:

With hypophosphorous acid; In pyridine; at 30 - 35 ℃;

DOI:10.1016/0040-4020(84)85114-5

Reference yield:

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine (69304-45-6) → Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (81244-12-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / Et₃N / DMAP / CH₂Cl₂ / 3 h

2: p-toluenesulfonic acid monohydrate / dioxane / 1 h

3: Et₄NBr, KF / acetonitrile; H₂O / 1.5 h / 53 °C

4: 89 percent / pyridine / 3 h / Ambient temperature

5: 88 percent / 1.) mesitylenedisulphonyl chloride / pyridine / 1.) 30 min; 2.) 1 h

6: phosphinic acid / pyridine / 30 - 35 °C

With potassium fluoride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; tetraethylammonium bromide; hypophosphorous acid; toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; pyridine; dichloromethane; water; acetonitrile;

DOI:10.1016/0040-4020(84)85114-5

Reference yield:

mono-4-methoxytrityl chloride (14470-28-1) → Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine (81244-12-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / Et₃N / DMAP / CH₂Cl₂ / 3 h

2: p-toluenesulfonic acid monohydrate / dioxane / 1 h

3: Et₄NBr, KF / acetonitrile; H₂O / 1.5 h / 53 °C

4: 89 percent / pyridine / 3 h / Ambient temperature

5: 88 percent / 1.) mesitylenedisulphonyl chloride / pyridine / 1.) 30 min; 2.) 1 h

6: phosphinic acid / pyridine / 30 - 35 °C

With potassium fluoride; 2,4,6-trimethyl-1,3-benzenedisulfonyl dichloride; tetraethylammonium bromide; hypophosphorous acid; toluene-4-sulfonic acid; triethylamine; dmap; In 1,4-dioxane; pyridine; dichloromethane; water; acetonitrile;

DOI:10.1016/0040-4020(84)85114-5

upstream raw materials:

Dithiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S,S'-diphenyl ester

triethylamine

3,4-dihydro-2H-pyran

3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine

Downstream raw materials:

C₁₀₉H₁₀₄N₁₀O₁₆P₂S₃

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 81244-12-4 Thiophosphoric acid O-[(2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-purin-9-yl)-4-(tetrahydro-pyran-2-yloxy)-tetrahydro-furan-3-yl] ester S-phenyl ester; compound with triethyl-amine

Send

Send

Metric Ton KG G Pound L ML

Send

Send