10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

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Chemical Name:10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide
CAS No.:239115-68-5
Molecular Formula:C₄₅H₇₈I₂N₈O₈S
Molecular Weight:1145.04
Hs Code.:

10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

Synonyms:10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

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Chemical Property of 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

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Technology Process of 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

There total 17 articles about 10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 86520-52-7
2-[2-(2-azidoethoxy)ethoxy]ethanol

: 239115-68-5
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 11 steps

1: 88 percent / Bu₄NBr, aq. NaOH / 5 h / 60 °C

2: 98 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h

3: 79 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

4: 91 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 0.5 h

5: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

6: H₂ / Pd(OH)2/C / methanol / 1 h

7: CH₂Cl₂ / 12 h

8: 97 percent / I₂, NaHCO₃ / methanol; H₂O / 0.5 h

9: 1.) C₆H₅SH, CF₃COOH / 1.) 1 h, 2.) CH₂Cl₂, 6 h

10: 73 percent / aq. NaOH / methanol / 3 h

11: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 2.) THF

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 4-nitro-phenol; 2-methyl-but-2-ene; tetrabutylammomium bromide; hydrogen; iodine; sodium hydrogencarbonate; benzotriazol-1-ol; Dess-Martin periodane; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0968-0896(99)00054-1

Reference yield:

: 52337-72-1
2-<2-(2-hydroxyethoxy)ethoxy>ethyl acetate

: 239115-68-5
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 13 steps

1: 97 percent / Et₃N / CH₂Cl₂ / 2 h / -78 °C

2: 1.) NaN₃, 2.) aq. NH₄OH / 1.) EtOH, H₂O, 80 deg C, 3 h, 2.) CH₃OH, 12 h

3: 88 percent / Bu₄NBr, aq. NaOH / 5 h / 60 °C

4: 98 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h

5: 79 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

6: 91 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 0.5 h

7: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

8: H₂ / Pd(OH)2/C / methanol / 1 h

9: CH₂Cl₂ / 12 h

10: 97 percent / I₂, NaHCO₃ / methanol; H₂O / 0.5 h

11: 1.) C₆H₅SH, CF₃COOH / 1.) 1 h, 2.) CH₂Cl₂, 6 h

12: 73 percent / aq. NaOH / methanol / 3 h

13: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 2.) THF

With ammonium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; sodium azide; 4-nitro-phenol; 2-methyl-but-2-ene; tetrabutylammomium bromide; hydrogen; iodine; sodium hydrogencarbonate; benzotriazol-1-ol; Dess-Martin periodane; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0968-0896(99)00054-1

Reference yield:

: 239115-49-2
methanesulfonic acid 10-(4-methoxy-benzyloxy)-decyl ester

: 239115-68-5
10-[2-(2-{2-[5-((3aR,6S,6aS)-2-Oxo-hexahydro-thieno[3,4-d]imidazol-6-yl)-pentanoylamino]-ethoxy}-ethoxy)-ethoxy]-decanoic acid [(S)-1-{3-[4-(3-amino-propylamino)-butylamino]-propylcarbamoyl}-2-(4-hydroxy-3,5-diiodo-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 12 steps

1: 99 percent / NaI / acetone / 3 h / Heating

2: 88 percent / Bu₄NBr, aq. NaOH / 5 h / 60 °C

3: 98 percent / 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂; H₂O / 1 h

4: 79 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h

5: 91 percent / NaClO₂, NaH₂PO₄, 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 0.5 h

6: 94 percent / 1-hydroxybenzotriazole, Et₃N, 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 18 h

7: H₂ / Pd(OH)2/C / methanol / 1 h

8: CH₂Cl₂ / 12 h

9: 97 percent / I₂, NaHCO₃ / methanol; H₂O / 0.5 h

10: 1.) C₆H₅SH, CF₃COOH / 1.) 1 h, 2.) CH₂Cl₂, 6 h

11: 73 percent / aq. NaOH / methanol / 3 h

12: 1.) p-nitrophenol, dicyclohexylcarbodiimide / 1.) THF, 2.) THF

With sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; 4-nitro-phenol; 2-methyl-but-2-ene; tetrabutylammomium bromide; hydrogen; iodine; sodium hydrogencarbonate; benzotriazol-1-ol; Dess-Martin periodane; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; sodium iodide; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1016/S0968-0896(99)00054-1