(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Chemical Name:(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid
CAS No.:80971-85-3
Molecular Formula:C₃₂H₄₁N₅O₈
Molecular Weight:623.706
Hs Code.:

(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Synonyms:(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Chemical Property of (S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

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Technology Process of (S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

There total 7 articles about (S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3978-80-1
Boc-Tyr-OH

: 80971-85-3
(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 2 M NaOH / 0 °C

2: 98 percent / Et₃N, N,N'-dicyclohexylcarbodiimide / dimethylformamide

3: 4 M HCl / dioxane / 1.5 h / Ambient temperature

4: 1.) CF₃COOH, anisole, 2.) IR-45(OAc)

With hydrogenchloride; sodium hydroxide; IR-45(OAc); methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 80971-82-0
(S)-3-(4-acetoxyphenyl)-2-[N-(tert.butoxycarbonyl)amino]propionic acid

: 80971-85-3
(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / Et₃N, N,N'-dicyclohexylcarbodiimide / dimethylformamide

2: 4 M HCl / dioxane / 1.5 h / Ambient temperature

3: 1.) CF₃COOH, anisole, 2.) IR-45(OAc)

With hydrogenchloride; IR-45(OAc); methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 1-(o-nitrophenylthio)aminocyclopropane-1-carbonylglycine p-nitrophenyl ester

: 80971-85-3
(S)-2-{(S)-2-[2-({1-[(S)-3-(4-Acetoxy-phenyl)-2-amino-propionylamino]-cyclopropanecarbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-4-methyl-pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / dimethylformamide / Ambient temperature

2: 99 percent / 1 M methanolic HCl / 0.5 h / Ambient temperature

3: 98 percent / Et₃N, N,N'-dicyclohexylcarbodiimide / dimethylformamide

4: 4 M HCl / dioxane / 1.5 h / Ambient temperature

5: 1.) CF₃COOH, anisole, 2.) IR-45(OAc)

With hydrogenchloride; IR-45(OAc); methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In 1,4-dioxane; N,N-dimethyl-formamide;