BENZYL 4-(BROMOPHENYL)-ETHER-D4

Base Information

• Chemical Name: BENZYL 4-(BROMOPHENYL)-ETHER-D4
• CAS No.: 1185020-84-1
• Molecular Formula: C₁₃H₁₁BrO
• Molecular Weight: 267.102
• Mol file: 1185020-84-1.mol

Synonyms:1-(benzyloxy)-4-bromobenzene-2,3,5,6-d₄

Chemical Property of BENZYL 4-(BROMOPHENYL)-ETHER-D4

Chemical Property:

• Solubility.: Methanol

Purity/Quality:

95% ^*data from raw suppliers

Benzyl4-(Bromophenyl)-ether-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BENZYL 4-(BROMOPHENYL)-ETHER-D4

There total 3 articles about BENZYL 4-(BROMOPHENYL)-ETHER-D4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-benzyloxyphenylbromide (6793-92-6) → 1-(benzyloxy)-4-bromobenzene-2,3,5,6-d4 (1185020-84-1)

Guidance literature:

With water-d2; potassium carbonate; silver carbonate; cyclohexyldiphenylphosphine; In toluene; at 120 ℃; for 12h;

DOI:10.1021/acs.orglett.0c04139

Reference yield: 63.0%

phenol-d5 (4165-62-2) + benzyl bromide (100-39-0) → 1-(benzyloxy)-4-bromobenzene-2,3,5,6-d4 (1185020-84-1)

Guidance literature:

phenol-d5; With bromine; In 1,4-dioxane;

benzyl bromide; With potassium carbonate;

DOI:10.1016/j.tetlet.2009.07.118

Reference yield:

benzyl bromide (100-39-0) + [2′,3′,5′,6′-d4]bromophenol (152404-44-9) → 1-(benzyloxy)-4-bromobenzene-2,3,5,6-d4 (1185020-84-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 4h; Inert atmosphere;

upstream raw materials:

phenol-d5

benzyl bromide

[2′,3′,5′,6′-d₄]bromophenol

p-benzyloxyphenylbromide

Downstream raw materials:

4-(benzyloxy)-2,3,5,6-tetradeuterobenzoic acid