3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

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Chemical Name:3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate
CAS No.:1613395-24-6
Molecular Formula:C₂HF₃O₂*C₂₄H₂₃FN₁₀O
Molecular Weight:600.535
Hs Code.:

Synonyms:3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

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Chemical Property of 3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

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Technology Process of 3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

There total 6 articles about 3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1613396-33-0
3-[4-amino-3-(4,5-dihydro-1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one

: 1613395-24-6
3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

Guidance literature:: With Dess-Martin periodane; In dimethyl sulfoxide; at 80 ℃; for 0.75h;

Reference yield:

: 1512322-11-0
1-(4-fluorophenyl)-5-isopropyl-1H-pyrazol-4-amine

: 1613395-24-6
3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: trimethylaluminum / 1,2-dichloro-ethane; toluene / 2.75 h / 20 - 50 °C

2: triethylamine / dichloromethane / 0.67 h / 0 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 50 °C

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

5: acetic acid / ethanol / 0.75 h / 100 °C

6: Dess-Martin periodane / dimethyl sulfoxide / 0.75 h / 80 °C

With trimethylaluminum; sodium hydride; potassium carbonate; Dess-Martin periodane; acetic acid; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1613396-30-7
4-amino-1-[1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-2-oxo-pyrrolidin-3-yl]pyrazolo[3,4-d]pyrimidine-3-carbonitrile

: 1613395-24-6
3-[4-amino-3-(1H-imidazol-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]-1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]pyrrolidin-2-one trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / ethanol / 0.75 h / 100 °C

2: Dess-Martin periodane / dimethyl sulfoxide / 0.75 h / 80 °C

With Dess-Martin periodane; acetic acid; In ethanol; dimethyl sulfoxide;