2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

Base Information

Chemical Name:2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide
CAS No.:1613396-15-8
Molecular Formula:C₁₆H₁₉BrFN₃O₂
Molecular Weight:384.248
Hs Code.:

Synonyms:2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

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Technology Process of 2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

There total 1 articles about 2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 5061-21-2
α-bromo-γ-butyrolactone

: 1512322-11-0
1-(4-fluorophenyl)-5-isopropyl-1H-pyrazol-4-amine

: 1613396-15-8
2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

Guidance literature:: With trimethylaluminum; In 1,2-dichloro-ethane; toluene; at 20 - 50 ℃; for 2.75h;

Reference yield: 99.0%

: 1613396-15-8
2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

: 124-63-0
methanesulfonyl chloride

: 1613396-17-0
C₁₇H₂₁BrFN₃O₄S

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.666667h;

Reference yield:

: 1613396-15-8
2-bromo-N-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-4-hydroxybutanamide

: 1613396-30-7
4-amino-1-[1-[1-(4-fluorophenyl)-5-isopropylpyrazol-4-yl]-2-oxo-pyrrolidin-3-yl]pyrazolo[3,4-d]pyrimidine-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.67 h / 0 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 50 °C

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 60 °C

With sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; mineral oil;