methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate

Base Information

• Chemical Name: methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate
• CAS No.: 114786-30-0
• Molecular Formula: C₃₀H₂₉N₃O₃
• Molecular Weight: 479.579

Synonyms:methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate

Chemical Property of methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate

Chemical Property:

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Technology Process of methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate

There total 3 articles about methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl-5-diphenylacetyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-1 H-imidazo[4,5-c ]pyridine-6-carboxylate (114786-25-3) + 1-bromomethyl-3-methyl-benzene (620-13-3) + sodium carbonate (497-19-8) → methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate (114786-30-0)

Guidance literature:

With acetic acid; zinc; In methanol; dichloromethane; acetonitrile;

Reference yield:

2,2-diphenylacetic acid (117-34-0) → methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate (114786-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide (DCC), hydroxybenztriazole (HOBT*H₂O) / dimethylformamide

2: 2.) glacial AcOH, Zn / 1.) CH₃CN, reflux, 2.) MeOH, sonication, 2 h

With benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jm00115a014

Reference yield:

(S)-3-(2-Oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-6-carboxylic acid methyl ester → methyl-1-(3-methylphenyl)methyl-5-diphenylacetyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylate (114786-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: dicyclohexylcarbodiimide (DCC), hydroxybenztriazole (HOBT*H₂O) / dimethylformamide

2: 2.) glacial AcOH, Zn / 1.) CH₃CN, reflux, 2.) MeOH, sonication, 2 h

With benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jm00115a014

upstream raw materials:

2,2-diphenylacetic acid

methyl-5-diphenylacetyl-3-(2-oxo-2-phenyl-ethyl)-4,5,6,7-tetrahydro-1 H-imidazo[4,5-c ]pyridine-6-carboxylate

1-bromomethyl-3-methyl-benzene

sodium carbonate

Downstream raw materials:

1H-imidazo[4,5-c]pyridine-6-carboxylic acid, 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-[(3-methylphenyl)methyl]-

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