methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

Base Information

Chemical Name:methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate
CAS No.:1367127-92-1
Molecular Formula:C₂₁H₁₆FNO₂
Molecular Weight:333.362
Hs Code.:

Synonyms:methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

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Chemical Property of methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

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Technology Process of methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

There total 5 articles about methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367127-90-9
methyl 4-chloro-6-(4'-fluoro-[1,1'-biphenyl]-4-yl)picolinate

: 75927-49-0
pinacol vinylboronate

: 1367127-92-1
methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

Guidance literature:: With tetrabutyl ammonium fluoride; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; at 60 ℃; Inert atmosphere;

Reference yield:

: 5467-74-3
4-Bromophenylboronic acid

: 1367127-92-1
methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 65 °C / Inert atmosphere

2: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 53 - 65 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 50 - 55 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 60 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1367127-92-1
methyl 6-(4'-fluoro-[1,1'-biphenyl]-4-yl)-4-vinylpicolinate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 65 °C / Inert atmosphere

2: potassium acetate / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / N,N-dimethyl-formamide / 53 - 65 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 50 - 55 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / palladium bis[bis(diphenylphosphino)ferrocene] dichloride / tetrahydrofuran / 60 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; potassium acetate; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;