5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

Base Information

Chemical Name:5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid
CAS No.:1192314-71-8
Molecular Formula:C₂₉H₁₈ClF₃N₂O₇S
Molecular Weight:630.985
Hs Code.:

Synonyms:5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

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Chemical Property of 5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

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Technology Process of 5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

There total 10 articles about 5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1192316-79-2
C₃₁H₂₂ClF₃N₂O₇S

: 1192314-71-8
5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

Guidance literature:: C₃₁H₂₂ClF₃N₂O₇S; With water; sodium hydroxide; In 1,4-dioxane; ethanol; at 65 ℃; for 0.5h;

In ethanol; diioxane; Acidification;

Reference yield:

: 393-85-1
methyl 5-fluoro-2-nitrobenzoate

: 1192314-71-8
5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / 18-crown-6 ether / DMF (N,N-dimethylformamide) / 3 h / 20 °C

2.1: hydrogenchloride; water / methanol / 0.83 h / Reflux

3.1: toluene / 1 h / Reflux

4.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 20 °C / 760.05 Torr

5.1: toluene / 0.5 h / Reflux

6.1: water; sodium hydroxide / 1,4-dioxane; ethanol / 0.5 h / 65 °C

6.2: Acidification

With hydrogenchloride; water; hydrogen; potassium carbonate; sodium hydroxide; 18-crown-6 ether; palladium 10% on activated carbon; In 1,4-dioxane; methanol; DMF (N,N-dimethylformamide); ethanol; ethyl acetate; toluene;

Reference yield:

: 1192318-92-5
methyl 2-amino-5-(3-(methoxycarbonyl)-4-nitrophenoxy)benzoate

: 1192314-71-8
5-[3-carboxy-4-(4-(trifluoromethylthio)-benzamido)-phenyloxy]-2-(3-chlorobenzamido)benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene / 1 h / Reflux

2.1: hydrogen / palladium 10% on activated carbon / ethanol; ethyl acetate / 20 °C / 760.05 Torr

3.1: toluene / 0.5 h / Reflux

4.1: water; sodium hydroxide / 1,4-dioxane; ethanol / 0.5 h / 65 °C

4.2: Acidification

With water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; ethyl acetate; toluene;