393-85-1

Basic information

• Product Name: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER
• Synonyms: METHYL 5-FLUORO-2-NITROBENZOATE;5-FLUORO-2-NITRO-BENZOIC ACID METHYL ESTER;2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER;RARECHEM AL BF 0375;Methyl 5-fluoro-2-nitrobenzoate 98%;Methyl5-fluoro-2-nitrobenzoate98%;5-Fluor-2-nitrobenzoesuremethylester;3-Methoxycarbonyl-4-nitrofluorobenzene
• CAS NO: 393-85-1
• Molecular Formula: C₈H₆FNO₄
• Molecular Weight: 199.14
• Product Categories: Aromatic Esters;Aromatics Compounds;Aromatics
• Mol File: 393-85-1.mol
• Article Data: 12

Chemical Properties

• Melting Point: 40-42°C
• Boiling Point: 282℃
• Flash Point: 124℃
• Appearance: White/Low Melting Solid
• Density: 1.388
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Acetone, DMSO
• Water Solubility: Slightly soluble in water. Soluble in dimethyl sulfoxide and acetone.
• CAS DataBase Reference: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER(393-85-1)
• EPA Substance Registry System: 2-NITRO-5-FLUOROBENZOIC ACID, METHYL ESTER(393-85-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 393-85-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Yellow Solid

Uses

2-Nitro-5-fluorobenzoic Acid, Methyl Ester (cas# 393-85-1) is a compound useful in organic synthesis.

InChI:InChI=1S/C8H6FNO4/c1-14-8(11)6-4-5(9)2-3-7(6)10(12)13/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 74-89-5 methylamine 
• 77-78-1 dimethyl sulfate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 455-68-5 methyl 3-fluorobenzoate 

Downstream Products

• 308805-05-2 Marchantin M trimethyl ether 
• 313520-26-2 C₂₈H₂₄O₅ 
• 308805-03-0 2-{2-[4-(5-Chloromethyl-2-methoxyphenoxy)phenyl]ethyl}-3-(3-chloromethylphenoxy)-1,4-dimethoxybenzene 
• 308805-02-9 [3-(4-{2-[2-(3-Hydroxymethylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxyphenyl]methanol 
• 308805-00-7 Methyl 3-(4-{2-[3,6-dimethoxy-2-(3-methyloxycarbonylphenoxy)phenyl]ethyl}phenoxy)-4-methoxybenzoate 
• 308804-98-0 Methyl 3-(4-{2-[2-(4-amino-3-methyloxycarbonylphenoxy)-3,6-dimethoxyphenyl]ethyl}phenoxy)-4-methoxybenzoate 
• 50594-67-7 5-[(2-chloro-α,α,α-trifluoro-p-tolyl)oxy]-2-nitrobenzoic acid,methyl ester 
• 946604-95-1 5-butoxy-2-nitrobenzoic acid methyl ester 
• 886978-05-8 methyl 5-[4-(ethylsulfonyl)phenoxy]-2-nitrobenzoate 
• 1192319-26-8 5-(3-tert-butoxycarbonylaminophenoxy)-2-nitrobenzoic acid methyl ester 
• 1192319-06-4 methyl 5-(4-(methylamino)phenoxy)-2-nitrobenzoate 
• 1192318-91-4 methyl 2-acetamido-5-(3-(methoxycarbonyl)-4-nitrophenoxy)-benzoate 
• 1192318-88-9 methyl 5-(2,2-dimethyl-4-oxo-4H-benzo[d][3,1]dioxin-6-yloxy)-2-nitrobenzoate 
• 1192319-12-2 methyl 5-(4-(4-fluorophenylamino)phenoxy)-2-nitrobenzoate 

Relevant articles and documents

Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors

SIRT6 is a deacetylase of histone H3 and inhibitors of SIRT6 have been thought as potential agents for treatment of diabetes. Herein we report the discovery of a series of new SIRT6 inhibitors containing the skeleton 1-phenylpiperazine. Among them, compound 5-(4-methylpiperazin-1-yl)-2-nitroaniline (6d) is the most potent one, which showed an IC50 value of 4.93 μM against SIRT6 in the Fluor de Lys (FDL) assay. It displayed KD values of 9.76 μM and 10 μM in surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) assays, respectively. In selectivity assay, 6d showed no activity against other members of the HDAC family (SIRT1-3 and HDAC1-11) at concentrations up to 200 μM. In a mouse model of type 2 diabetes, 6d could significantly increase the level of glucose transporter GLUT-1, thereby reducing blood glucose. Overall, this study provides a promising lead compound for subsequent drug discovery targeting SIRT6.

Synthesis of 2′,3′-dideoxynucleosides for automated DNA synthesis and pyrophosphorolysis activated polymerization

Methods for preparation of 2′,3′-dideoxynucleotides support structures, such as 2′,3′-dideoxyguanosine, 2′,3′-dideoxyadenosine, and 3′-deoxythymidine support structures are disclosed. Various methods of using such structures are also provided, such as their use for automated DNA synthesis and pyrophosphorolysis activated polymerization.

SUBSTITUTED AMINO-QUINAZOLINONES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE

The present invention relates to substituted amino-quinazolinones of general formula (I) wherein the groups R1 to R14 and A, are defined as in the specification and claims and the use thereof for the treatment of Alzheimer's disease (AD) and similar diseases.