[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

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Chemical Name:[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone
CAS No.:1370531-45-5
Molecular Formula:C₂₃H₂₇N₃OS₃
Molecular Weight:457.685
Hs Code.:

Synonyms:[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

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Chemical Property of [2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

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Technology Process of [2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

There total 15 articles about [2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1370531-42-2
[4-(1,3-benzothiazol-2-yl)-2-nitrophenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

: 1370531-45-5
[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

Guidance literature:: With tin(II) chloride dihdyrate; In methanol; for 1h; Reflux;
DOI:10.1016/j.ejmech.2012.01.014

Reference yield:

: 96-98-0
4-methyl-3-nitrobenzoic acid

: 1370531-45-5
[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride; N,N-dimethyl-formamide / benzene / 80 °C

2: triethylamine / tetrahydrofuran / 0 - 20 °C

3: Lawessons reagent / toluene / 60 °C / Reflux

4: Dess-Martin periodane / dichloromethane / 20 °C

5: pyridine; tetra-n-butylammonium permanganate / 12 h / 20 °C

6: thionyl chloride; N,N-dimethyl-formamide / benzene / Reflux

7: triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

8: tin(II) chloride dihdyrate / methanol / 1 h / Reflux

With Lawessons reagent; pyridine; thionyl chloride; tetra-n-butylammonium permanganate; tin(II) chloride dihdyrate; Dess-Martin periodane; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; toluene; benzene;
DOI:10.1016/j.ejmech.2012.01.014

Reference yield:

: 10397-30-5
4-methyl-3-nitrobenzoyl chloride

: 1370531-45-5
[2-amino-4-(1,3-benzothiazol-2-yl)phenyl](2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-1-pyrrolylmethanone

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / 0 - 20 °C

2: Lawessons reagent / toluene / 60 °C / Reflux

3: Dess-Martin periodane / dichloromethane / 20 °C

4: pyridine; tetra-n-butylammonium permanganate / 12 h / 20 °C

5: thionyl chloride; N,N-dimethyl-formamide / benzene / Reflux

6: triethylamine / tetrahydrofuran / 1.5 h / 0 - 20 °C

7: tin(II) chloride dihdyrate / methanol / 1 h / Reflux

With Lawessons reagent; pyridine; thionyl chloride; tetra-n-butylammonium permanganate; tin(II) chloride dihdyrate; Dess-Martin periodane; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; toluene; benzene;
DOI:10.1016/j.ejmech.2012.01.014