Technology Process of methyl 2-(((benzyloxy)carbonyl)amino)-1-methyl-1H-indole-3-carboxylate
There total 6 articles about methyl 2-(((benzyloxy)carbonyl)amino)-1-methyl-1H-indole-3-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(methoxycarbonyl)-1-methyl-1H-indole-2-carboxylic acid;
With
diphenyl phosphoryl azide; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
under 760.051 Torr;
Cooling with ice;
benzyl alcohol;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 3h;
under 760.051 Torr;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: oxygen; palladium diacetate; acetic acid / N,N-dimethyl acetamide / 18 h / 115 °C / 760.05 Torr
2.1: sodium hydride / 8 h / 0 - 75 °C / 760.05 Torr
3.1: potassium hydroxide / ethanol / 8 h / 760.05 Torr / Reflux
4.1: trifluoroacetic anhydride / dichloromethane / 2 h / 760.05 Torr
5.1: trifluoroacetic anhydride / 18 h / 20 °C / 760.05 Torr
6.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C / 760.05 Torr / Cooling with ice
6.2: 3 h / 80 °C / 760.05 Torr
With
diphenyl phosphoryl azide; oxygen; palladium diacetate; sodium hydride; acetic acid; triethylamine; trifluoroacetic anhydride; potassium hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / 8 h / 0 - 75 °C / 760.05 Torr
2.1: potassium hydroxide / ethanol / 8 h / 760.05 Torr / Reflux
3.1: trifluoroacetic anhydride / dichloromethane / 2 h / 760.05 Torr
4.1: trifluoroacetic anhydride / 18 h / 20 °C / 760.05 Torr
5.1: triethylamine; diphenyl phosphoryl azide / N,N-dimethyl-formamide / 2 h / 20 °C / 760.05 Torr / Cooling with ice
5.2: 3 h / 80 °C / 760.05 Torr
With
diphenyl phosphoryl azide; sodium hydride; triethylamine; trifluoroacetic anhydride; potassium hydroxide;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
