tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate
CAS No.:1312793-84-2
Molecular Formula:C₂₀H₂₇N₃O₅
Molecular Weight:389.451
Hs Code.:

Synonyms:tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

There total 6 articles about tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 40312-16-1
N'-hydroxy-3,4-dimethoxybenzimidamide

: 84358-13-4,174286-31-8
N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid

: 1312793-84-2
tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Guidance literature:: N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

N'-hydroxy-3,4-dimethoxybenzimidamide; In N,N-dimethyl-formamide; at 0 - 110 ℃; for 13.5h; Inert atmosphere;
DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

: C₂₀H₂₉N₃O₆

: 1312793-84-2
tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.03.031

Reference yield:

: 2024-83-1
veratronitrile

: 1312793-84-2
tert-butyl 4-(3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydroxylamine hydrochloride; sodium carbonate / ethanol; water / 18 h / 0 °C / Reflux

2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 3.5 h / 0 - 30 °C / Inert atmosphere

3.1: N,N-dimethyl-formamide / 10 h / 110 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium carbonate; dicyclohexyl-carbodiimide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2011.03.031