2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone
• CAS No.: 15485-64-0
• Molecular Formula: C14H11 Cl O3
• Molecular Weight: 262.693
• Hs Code.: 2914700090
• Mol file: 15485-64-0.mol

Synonyms:Acetophenone,2-(p-chlorophenyl)-2',4'-dihydroxy- (6CI,8CI)

Chemical Property of 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone

Chemical Property:

• Melting Point: 153-154 °C
• Boiling Point: 456.0±14.0 °C(Predicted)
• PKA: 7.60±0.35(Predicted)
• PSA: 57.53000
• Density: 1.379±0.06 g/cm3(Predicted)
• LogP: 3.17660

Purity/Quality:

98% ^*data from raw suppliers

2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone

There total 8 articles about 2-(4-Chlorophenyl)-1-(2,4-dihydroxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-chlorophenylacetic Acid (1878-66-6) + recorcinol (108-46-3) → 2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)ethan-1-one (15485-64-0)

Guidance literature:

With boron trifluoride diethyl etherate; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.01.032

Reference yield: 78.0%

recorcinol (108-46-3) + p-chlorobenzyl cyanide (140-53-4) → 2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)ethan-1-one (15485-64-0)

Guidance literature:

recorcinol; p-chlorobenzyl cyanide; With hydrogenchloride; boron trifluoride diethyl etherate;

With water; at 80 ℃;

DOI:10.1007/s10600-019-02821-5

Reference yield: 49.0%

→ 2-(4-chlorophenyl)-1-(2,4-dihydroxyphenyl)ethan-1-one (15485-64-0)

Guidance literature:

With boron trifluoride diethyl etherate; at 85 ℃; Inert atmosphere;

upstream raw materials:

4-chlorophenacetyl chloride

recorcinol

p-chlorobenzyl cyanide

4-chlorophenylacetic Acid

Downstream raw materials:

3-(4-chlorophenyl)-7-hydroxy-4-oxo-4H-1-benzopyran-8-carboxaldehyde

7-hydroxy-3-(4'-chlorophenyl)-4H-1-benzopyran-4-one

N-({[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetyl)glycine

{[2-methyl-4-oxo-3-(4-chlorophenyl)-4H-chromen-7-yl]oxy}acetic acid

Refernces

• 1、 Tang, Buyun,Frasinyuk, Mykhaylo S.,Chikwana, Vimbai M.,Mahalingan, Krishna K.,Morgan, Cynthia A.,Segvich, Dyann M.,Bondarenko, Svitlana P.,Mrug, Galyna P.,Wyrebek, Przemyslaw,Watt, David S.,Depaoli-Roach, Anna A.,Roach, Peter J.,Hurley, Thomas D.. "Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase". . p. 3538 - 3551. Retrieved 2020/04/30.
• 2、 -. "CYTISINE-LINKED ISOFLAVONOID ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER". Paragraph 0063; 0066. . Retrieved 2019/01/04.