(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Base Information

Chemical Name:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide
CAS No.:1269662-70-5
Molecular Formula:C₃₁H₂₉ClN₆O₃
Molecular Weight:569.063
Hs Code.:

Synonyms:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Suppliers and Price of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

There total 5 articles about (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.6%

: 1269662-80-7
(2S)-2-[(E)-3-[[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxyquinolin-6-yl]amino]-3-oxopropen-1-yl]pyrrolidine-1-carboxylic acid tert-butyl ester

: 1269662-70-5
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 12h;

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 1269662-70-5
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.75 h / Cooling with dry ice

1.2: 1 h / 0 °C / Cooling with dry ice

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.75 h / Cooling with dry ice

2.2: 13 h / 20 °C / Cooling with dry ice

3.1: hydrogenchloride / 1,4-dioxane / 12 h

With hydrogenchloride; oxalyl dichloride; dimethyl sulfoxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene;

Reference yield:

: 848139-78-6
6-amino-4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-7-ethoxyquinoline-3-carbonitrile

: 1269662-70-5
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolinyl]-3-[(2S)-pyrrolidin-2-yl]propan-2-enoylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 40 °C

1.2: 12 h / 40 °C

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.75 h / Cooling with dry ice

2.2: 13 h / 20 °C / Cooling with dry ice

3.1: hydrogenchloride / 1,4-dioxane / 12 h

With hydrogenchloride; 1,1'-carbonyldiimidazole; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; toluene;