3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

Base Information

Chemical Name:3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid
CAS No.:252232-76-1
Molecular Formula:C₂₆H₂₁FN₄O₄
Molecular Weight:472.476
Hs Code.:

Synonyms:3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

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Chemical Property of 3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

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Technology Process of 3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

There total 10 articles about 3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 252232-75-0
1-(4-fluorophenylmethyl)-6-(4-cyano-2-propoxyphenyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

: 252232-76-1
3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 5h; Heating;
DOI:10.1021/jm000081+

Reference yield: 75.0%

: 252232-76-1
3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

Guidance literature:

Reference yield:

: 136833-36-8
5-chloro-2,4-dinitrobenzoic acid

: 252232-76-1
3-[1-[(4-Fluorophenyl)methyl]-7,8-dihydro-8-oxo-1H-imidazo[4,5-g]-quinazolin-6-yl]-4-propoxybenzoic acid

Guidance literature:: Multi-step reaction with 9 steps

1: SOCl₂ / dimethylformamide / 4 h / Heating

2: conc. aq. NH₄OH / 0.5 h / 0 °C

3: 81 percent / Et₃N / tetrahydrofuran / Heating

4: H₂ / PtO / methanol / 5 h

5: 20 °C

6: EDAC; HOBt / DMAP / dimethylformamide / 2 h / 20 °C

7: KOtBu / 2-methyl-propan-2-ol / 45 h / Heating

8: 91 percent / N-methyl-2-pyrrolidinone / Heating

9: 75 percent / aq. NaOH / ethanol / 5 h / Heating

With 1-methyl-pyrrolidin-2-one; ammonium hydroxide; sodium hydroxide; thionyl chloride; potassium tert-butylate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; platinum(II) oxide; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol; 1: Chlorination / 2: Substitution / 3: Substitution / 4: Catalytic hydrogenation / 5: Cyclization / 6: Substitution / 7: Cyclization / 8: Substitution / 9: Hydrolysis;
DOI:10.1021/jm000081+