Technology Process of 4,4''-dimethoxy-5'-{4-[2-(phenylmethyl)benzo[b]thien-3-yl]phenyl}-[1,1';3',1''-terphenyl]-2'-ol
There total 10 articles about 4,4''-dimethoxy-5'-{4-[2-(phenylmethyl)benzo[b]thien-3-yl]phenyl}-[1,1';3',1''-terphenyl]-2'-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
barium dihydroxide; palladium diacetate;
In
1,2-dimethoxyethane; water;
at 75 ℃;
for 10h;
DOI:10.1021/jm990560c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 85 percent / Pd(OAc)2; aq. K2CO3 / acetone / 2 h / 65 °C
2.1: BBr3 / CH2Cl2 / 10 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C
3.2: tetrahydrofuran / 0.5 h / 0 °C
4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C
4.2: KOH / 10 h / 130 °C
5.1: Br2; KOAc / acetic acid / 0.17 h / 5 °C
6.1: 41 percent / palladium(II) acetate; barium hydroxide / 1,2-dimethoxy-ethane; H2O / 10 h / 75 °C
With
palladium diacetate; barium dihydroxide; n-butyllithium; bromine; potassium acetate; palladium diacetate; boron tribromide; potassium carbonate; hydrazine hydrate; diethylene glycol;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetic acid; acetone;
1.1: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Substitution;
DOI:10.1021/jm990560c
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi; tetramethylenediamine / diethyl ether / 12 h / 20 °C
1.2: 23 percent / diethyl ether / 20 h / 20 °C
2.1: BBr3 / CH2Cl2 / 10 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C
3.2: tetrahydrofuran / 0.5 h / 0 °C
4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C
4.2: KOH / 10 h / 130 °C
5.1: Br2; KOAc / acetic acid / 0.17 h / 5 °C
6.1: 41 percent / palladium(II) acetate; barium hydroxide / 1,2-dimethoxy-ethane; H2O / 10 h / 75 °C
With
barium dihydroxide; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; bromine; potassium acetate; palladium diacetate; boron tribromide; hydrazine hydrate; diethylene glycol;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; acetic acid;
1.1: Metallation / 1.2: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Substitution;
DOI:10.1021/jm990560c
