5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

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Chemical Name:5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine
CAS No.:1377550-27-0
Molecular Formula:C₂₅H₂₅N₇O₃S
Molecular Weight:503.585
Hs Code.:

Synonyms:5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

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Chemical Property of 5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

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Technology Process of 5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

There total 6 articles about 5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7752-82-1
5-bromo-2-aminopyrimidine

: 1377551-51-3
2-(4-methoxyphenyl)-3-(4-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl)piperazin-1-yl)pyrazine

: 1377550-27-0
5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1h;
DOI:10.1021/jm300403a

Reference yield:

: 313654-83-0
2-Chloro-3-(4-tert-butoxycarbonyl-1-piperazinyl)pyrazine

: 1377550-27-0
5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 0 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 70 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / monoethylene glycol diethyl ether / 2 h / 90 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; monoethylene glycol diethyl ether; water; 3: Suzuki-Miyaura cross-coupling / 4: Suzuki-Miyaura cross-coupling / 5: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a

Reference yield:

: 1377551-31-9
C₁₄H₁₄BrClN₄O₂S

: 1377550-27-0
5-(3-(4-(3-(4-methoxyphenyl)pyrazin-2-yl)piperazin-1-ylsulfonyl)phenyl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 2 h / 70 °C

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / monoethylene glycol diethyl ether / 2 h / 90 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 1 h / 90 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; In 1,4-dioxane; monoethylene glycol diethyl ether; water; 1: Suzuki-Miyaura cross-coupling / 2: Suzuki-Miyaura cross-coupling / 3: Suzuki-Miyaura cross-coupling;
DOI:10.1021/jm300403a