(Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

Base Information

Chemical Name:(Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate
CAS No.:662110-21-6
Molecular Formula:C₁₂H₁₂ClNO₇S
Molecular Weight:349.749
Hs Code.:

Synonyms:(Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

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Chemical Property of (Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

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Technology Process of (Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

There total 2 articles about (Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 124-63-0
methanesulfonyl chloride

: 662110-16-9
methyl 3-(4-chlorophenyl)-2,3-dihydroxy-2-nitromethylpropionate

: 662110-21-6
(Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

Guidance literature:: With triethylamine; In dichloromethane; at -20 ℃; for 0.5h;
DOI:10.1016/j.tet.2003.11.013

Reference yield:

: 131469-67-5
methyl 2-[1-hydroxy-1-(4-chlorophenyl)methyl]acrylate

: 662110-21-6
(Z)-methyl 2-[(4-chlorophenyl)(methanesulfonyloxy)methyl]-3-nitroacrylate

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / ceric ammonium nitrate; sodium nitrite / acetonitrile / 24 h / 20 °C

2: 79 percent / triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

With ammonium cerium(IV) nitrate; triethylamine; sodium nitrite; In dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2003.11.013