phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

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Chemical Name:phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester
CAS No.:418760-12-0
Molecular Formula:C₄₂H₄₈N₇O₁₃P
Molecular Weight:889.856
Hs Code.:

phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Synonyms:phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

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Chemical Property of phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

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Technology Process of phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

There total 6 articles about phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 418759-91-8
C₄₈H₆₂N₇O₁₃PSi

: 418760-12-0
phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 25 ℃;
DOI:10.1021/ja012135q

Reference yield:

: [(2R,3S)-5-(6-Amino-5-nitro-pyrimidin-4-ylamino)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-methanol

: 418760-12-0
phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: tetrazole / acetonitrile / 2 h / 25 °C

2: t-BuOOH / decane; acetonitrile / 25 °C

3: H₂ / Pd/CaCO₃ / methanol; tetrahydrofuran / 1551.49 Torr

4: pyridine / tetrahydrofuran / 0 - 20 °C

5: 57 percent / Bu₄NF*3H₂O; AcOH / tetrahydrofuran / 25 °C

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; Lindlar's catalyst; In tetrahydrofuran; methanol; decane; acetonitrile;
DOI:10.1021/ja012135q

Reference yield:

: C₄₇H₆₀N₇O₁₄PSi

: 418760-12-0
phosphoric acid 5-(6-amino-5-formylamino-pyrimidin-4-ylamino)-3-hydroxy-tetrahydro-furan-2-ylmethyl ester 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/CaCO₃ / methanol; tetrahydrofuran / 1551.49 Torr

2: pyridine / tetrahydrofuran / 0 - 20 °C

3: 57 percent / Bu₄NF*3H₂O; AcOH / tetrahydrofuran / 25 °C

With pyridine; tetrabutyl ammonium fluoride; hydrogen; acetic acid; Lindlar's catalyst; In tetrahydrofuran; methanol;
DOI:10.1021/ja012135q