5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

Base Information

• Chemical Name: 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE
• CAS No.: 84416-85-3
• Molecular Formula: C38H48 N3 O8 P
• Molecular Weight: 705.788
• Mol file: 84416-85-3.mol

Synonyms:5’-O-(4,4’-DIMETHOXYTRITYL)-2’-DEOXYTHYMIDINE-3’-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE;DMT-THYMIDINE O-METHYL PHOSPHORAMIDITE);dimethoxytrityl-thymidine phosphoramidite

Chemical Property of 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

Chemical Property:

• PSA: 140.62000
• LogP: 6.82920
• Storage Temp.: Store at -20°C

Purity/Quality:

97% ^*data from raw suppliers

5'-OXO-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE

There total 11 articles about 5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYTHYMIDINE-3'-(METHYL-N,N-DIISOPROPYL)PHOSPHORAMIDITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

bis(N,N-diisopropylamino)methoxyphosphine (92611-10-4) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → [5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-85-3)

Guidance literature:

With N,N-diisopropylamine tetrazolide;

DOI:10.1080/15257779408011881

Reference yield: 80.0%

monochloro-N,N-diisopropylaminothiomethoxyphosphine (121667-95-6) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → N,N-diisopropylamino-3'-O-<5'-O-(dimethoxytrityl) thymidine>thiomethoxyphosphine (121667-97-8,121668-00-6) + [5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-85-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(00)88455-5

Reference yield: 74.0%

N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) + 5'-O-(4-4'-dimethoxytrityl)thymidine (40615-39-2) → [5'-O-(4,4'-dimethoxytrityl)thymidine-3'-yl]-(N,N'-diisopropyl)methylphosphoramidite (84416-85-3)

Guidance literature:

DOI:10.1021/jo00225a062

upstream raw materials:

methanol

N,N-diisopropylphosphoramide dichloride

5'-O-(4-4'-dimethoxytrityl)thymidine

N,N-diisopropylmethylphosphonamidic chloride

Downstream raw materials:

C₅₂H₅₄N₇O₁₄PS

3'-O-acetyl-5'-O-(4,4'-dimethoxytrityl)-dithymidylyl-3',5'-O-methylphosphate

C₆₅H₆₅N₆O₁₅P

C₄₈H₆₁N₄O₁₃PSi

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